Paclitaxel Induces Acute Pain via Directly Activating Toll like Receptor 4
نویسندگان
چکیده
منابع مشابه
Paclitaxel induces acute pain via directly activating toll like receptor 4
Paclitaxel, a powerful anti-neoplastic drug, often causes pathological pain, which significantly reduces the quality of life in patients. Paclitaxel-induced pain includes pain that occurs immediately after paclitaxel treatment (paclitaxel-associated acute pain syndrome, P-APS) and pain that persists for weeks to years after cessation of paclitaxel treatment (paclitaxel induced chronic neuropath...
متن کاملClinical Value of Toll Like Receptor 4 and CD14 in Children with Acute Lower Respiratory Tract Infection
Toll like receptors (TLRs) with a myeloid differentiation antigen (CD14) recognize and bind various structures from invading microbes and then trigger cell activation. They initiate a variety of effectors' functions, including cytokine secretion, proliferation, co-stimulation or phagocyte maturation. The aim of this study was to evaluate Toll-like receptor 4 (TLR4) and CD14 expression in childr...
متن کاملMinimally modified low-density lipoprotein induces macrophage endoplasmic reticulum stress via toll-like receptor 4.
Minimally modified low-density lipoprotein (mm-LDL) induces intimal foam cell formation, which is promoted by endoplasmic reticulum stress (ERS), a cross-point to link cellular processes with multiple risk factors that exist in all stages of atherosclerosis. However, it remains unclear whether mm-LDL-induced lipid accumulation in macrophages involves ERS and its underlying mechanisms. We showed...
متن کاملCampylobacter jejuni Induces Acute Enterocolitis in Gnotobiotic IL-10−/− Mice via Toll-Like-Receptor-2 and -4 Signaling
BACKGROUND Campylobacter jejuni is a leading cause of foodborne bacterial enterocolitis worldwide. Investigation of immunopathology is hampered by a lack of suitable vertebrate models. We have recently shown that gnotobiotic mice as well as conventional IL-10(-/-) animals are susceptible to C. jejuni infection and develop intestinal immune responses. However, clinical symptoms of C. jejuni infe...
متن کاملHyaluronan inhibits osteoclast differentiation via Toll-like receptor 4.
The differentiation of osteoclasts, cells specialized for bone resorption, is governed by two key factors, macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor kappaB ligand (RANKL). The extracellular matrix (ECM) is an important factor influencing cell fate. To date, little investigation on the relationship between ECM components and osteoclast differentiation ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Pain
سال: 2015
ISSN: 1744-8069,1744-8069
DOI: 10.1186/s12990-015-0005-6